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KMID : 0984720050370030133
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Infection and Chemotherapy
2005 Volume.37 No. 3 p.133 ~ p.137
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In vitro Antimicrobial Activity of Cefcapene against Clinical Isolates
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Choo Eun-Ju
Kwak Yee-Gyung
Lee Mi-Suk
Jeong Jin-Yong
Choi Sang-Ho
Kim Nam-Joong
Kim Yang-Soo
Woo Jun-Hee
Ryu Ji-So
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Abstract
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Background: Cefcapene pivoxil hydrochloride is a new oral cephem which has a broad-spectrum activity with expanded potency against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus, as well as Gram-negative bacteria. In this study, we examined the in vitro activity of cefcapene against recently isolated clinical specimens from patients in a tertiary hospital.
Materials & Methods: We tested the in vitro antimicrobial activities of cefcapene and other cephalosporins against 450 clinical isolates from of patients in Asan Medical Center. Minimal inhibitory concentrations (MICs) were determined by agar dilution method according to the recommendations of National Committee for Clinical Laboratory Standards.
Results: Compared with other cephalosporins (cefaclor, cefpodoxime, and cefixime), cefcapene had lower MIC distributions for Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and methicillin-susceptible S. aureus. Cefcapene had variable activity against Enterobateriaceae.
Conclusion: Cefcapene had excellent in vitro antimicrobial activities against common typical bacterial respiratory tract pathogens and methicillin-susceptible S. aureus. Cefcapene appears to be a promising agent for treatment of community-acquired respiratory tract infections and infections caused by methicillin-susceptible S. aureus.
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KEYWORD
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Cefcapene, Cephalosporin, Minimal inhibitory concentrations
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